A new, ambitious Global Strategy for Women’s, Children’s and Adolescents’ Health aims to enable all women, children and adolescents to reach their full potential through three sets of goals labelled Survive, Thrive and Transform. Targets have been set to end preventable maternal, newborn and child deaths and to improve the health of women, children and adolescents by 2030. Countries and partners are mobilizing to increase—and enhance the use of domestic and global financial resources to achieve these results. The launch of the Global Financing Facility in July 2015 is one important contribution to this process alongside the new Global Strategy and the Sustainable Development Goals. These new opportunities require that countries and partners work intensively together and shift from using a “shopping list” approach to planning and financing national plans for improving the health of women, children and adolescents, to a more strategic and compelling “investment case” approach.