Human-centered design (HCD) is increasingly being applied in global health programs, but its application varies widely across projects, and its documentation is limited. With an aim to expand the knowledge base, the Beyond Bias project has documented, in a three-part series, its experience using HCD in a multidisciplinary approach to develop effective, scalable adolescent and youth sexual and reproductive health interventions. The briefs cover programmatic challenges and opportunities, outline salient ideas and concepts that were generated and tested, share key insights on provider bias, and present the finalized intervention design.