Global responses to the coronavirus disease 2019 (COVID-19) pandemic are converging with pervasive, existing sexual and reproductive health and justice inequities to disproportionately impact the health, wellbeing, and economic stability of women, girls, and vulnerable populations. People whose human rights are least protected are likely to experience unique difficulties from COVID-19. Women, girls, and marginalised groups are likely to carry a heavier burden of what will be the devastating downstream economic and social consequences of this pandemic. A sexual and reproductive health and justice framework—one that centres human rights, acknowledges intersecting injustices, recognises power structures, and unites across identities—is essential for monitoring and addressing the inequitable gender, health, and social effects of COVID-19.